Astemizole: CYP3A4 Inhibitors Strong may increase the serum concentration of Astemizole. Gulnik SV, Suvorov LI, Liu B et al. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry. Tozzi V "Pharmacogenetics of antiretrovirals. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy.
Haas DW, Fessel WJ, Delapenha RA et al. Therapy with efavirenz plus indinavir in patients with extensive prior nucleoside reverse-transcriptase inhibitor experience: a randomized, double-blind, placebo-controlled trial. J Infect Dis. The mechanism and long-term consequences of these events are currently unknown. A causal relationship has not been established. Parecoxib: CYP3A4 Inhibitors Strong may increase the serum concentration of Parecoxib.
Psychiatric side effects have included anxiety and neurosis. Depression has been reported during postmarketing experience. Crixivan is not a cure for HIV-1 infection and patients may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections. Patients should remain under the care of a physician when using Crixivan. Hepatitis, hepatic failure, hepatic cytolysis, pancreatitis including at least one case with lactic acidosis jaundice, liver function abnormalities, increased serum triglycerides, and cirrhosis have been reported during postmarketing experience.
An increase in how much alcohol you drink. Gagnon AM, Angel JB, Sorisky A. Protease inhibitors and adipocyte differentiation in cell culture. Lancet. Isolates of HIV-1 with reduced susceptibility to the drug have been recovered from some patients treated with indinavir. Viral resistance was correlated with the accumulation of mutations that resulted in the expression of amino acid substitutions in the viral protease. Effect of Food on Oral Absorption.
What other drugs will affect alosetron Lotronex? CRIXIVAN must be taken at intervals of 8 hours. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, and QT prolongation see above. In some patients with hemophilia, increased bleeding has been reported. Use indinavir as directed by your doctor. Check the label on the medicine for exact dosing instructions. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. American Thoracic Society ATS and Centers for Disease Control and Prevention CDC. Targeted tuberculin testing and treatment of latent tuberculosis infections. Am J Respir Crit Care Med. Invirase saquinavir mesylate US prescribing information. Drugs for HIV infection. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Rifabutin: Indinavir may increase serum concentrations of the active metabolites of Rifabutin. Rifabutin may decrease the serum concentration of Indinavir. Indinavir may increase the serum concentration of Rifabutin. Management: Reduce rifabutin dose by 50% and increase adult indinavir dose to 1 g every 8 hours, per US labeling. Proton Pump Inhibitors: May decrease the serum concentration of Indinavir. Significant accumulation was not observed after multiple dosing at 800 mg every 8 hours. Feigal DW Jr. Dear healthcare provider letter: HIV protease inhibitors and patients with hemophilia. Anderson PL "Pharmacologic perspectives for once-daily antiretroviral therapy. Indinavir may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection eg, fever, sore throat, weakness, cough, shortness of breath after you start indinavir.
It is unknown if this medication passes into breast milk. Because breast milk can transmit HIV, do not breast-feed. Sildenafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Sildenafil. Management: Use of sildenafil for pulmonary hypertension should be avoided with strong CYP3A4 inhibitors. When used for erectile dysfunction, starting adult dose should be reduced to 25 mg. Maximum adult dose with ritonavir or cobicistat is 25 mg per 48 hours. Suvorexant: CYP3A4 Inhibitors Strong may increase the serum concentration of Suvorexant. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Toremifene. CYP3A4 Inhibitors Strong may increase the serum concentration of Toremifene. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. entocort
What is the most important information I should know about alosetron Lotronex? Tell your doctor or dentist that you take indinavir before you receive any medical or dental care, emergency care, or surgery. Noor MA, Lo JC, Mulligan K, Schwarz JM, Halvorsen RA, Schambelan M, Grunfeld C "Metabolic effects of indinavir in healthy HIV-seronegative men. Olaparib: CYP3A4 Inhibitors Strong may increase the serum concentration of Olaparib. Management: Avoid use of strong CYP3A4 inhibitors in patients being treated with olaparib. If such concurrent use cannot be avoided, the dose of olaparib should be reduced to 150 mg twice daily. GlaxoSmithKline, Research Triangle Park, NC 27709. Revised: June 2015. Domperidone: CYP3A4 Inhibitors Strong may increase the serum concentration of Domperidone. Only take medicine that your doctor has prescribed specially for you. Do not share your medicine with others. Avanafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Avanafil. Pfizer. Vfend voriconazole prescribing information. New York, NY; 2011 Nov. ONGLYZA 5 mg group and 5 units for the placebo group. The atorvastatin and rosuvastatin doses should be carefully titrated; use the lowest dose necessary with careful monitoring during treatment with CRIXIVAN. Kline MW, Fletcher CV, Harris AT et al. A pilot study of combination therapy with indinavir, stavudine d4T and didanosine ddI in children infected with the human immunodeficiency virus. J Pediatr. ViiV Healthcare. Selzentry maraviroc tablets prescribing information. Research Triangle Park, NC; 2011 Nov. lzip.info femara
Store at room temperature away from moisture, heat, and light. Diabetes and high blood sugar hyperglycemia have occurred in patients taking protease inhibitors. In some of these patients, this led to ketoacidosis, a serious condition caused by poorly controlled blood sugar. Some patients had diabetes before starting protease inhibitors, others did not. Some patients required adjustments to their diabetes medication. Others needed new diabetes medication. Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. NIH. National Institutes of Health "Guidelines for the use of antiretroviral agents in pediatric HIV infection. Must be taken with food. Distributed into CSF in low concentration in adults 21 or children. If you miss a dose or forget to use your medicine less than 2 hours, use it as soon as you can. If your next regular dose is more than 2 hours, wait until then to use the medicine and skip the missed dose. ONGLYZA 5 mg add-on to TZD group, and 10% in the placebo add-on to TZD group. The pharmacokinetics of indinavir have not been studied in patients with renal insufficiency. Using any of them together with indinavir may increase the chance of serious side effects. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Some kidney stones are struvite stones. Henry K, Melroe H, Huebesch J et al. Atorvastatin and gemfibrozil for protease- inhibitor-related lipid abnormalities. Lancet. Tacrolimus Systemic: Protease Inhibitors may decrease the metabolism of Tacrolimus Systemic. Experts state ritonavir-boosted indinavir not recommended for initial treatment regimens in antiretroviral-naive pregnant women because of potential to cause kidney stones and hyperbilirubinemia. 202 In addition, data insufficient to recommend appropriate dosage of ritonavir-boosted indinavir for pregnant women.
Taking Crixivan with the above medications could result in serious or life-threatening problems such as irregular heartbeat or excessive sleepiness. Indinavir may also be taken with other liquids eg, skim milk, juice, coffee, or tea or with a light meal eg, dry toast with jelly, juice, coffee with skim milk and sugar, or corn flakes with skim milk and sugar. Both Crixivan and atazanavir are associated with indirect unconjugated hyperbilirubinemia. Combinations of these drugs have not been studied and coadministration of Crixivan and atazanavir is not recommended. ONGLYZA and placebo respectively. Lipitor atorvastatin US prescribing information. Pfizer Inc. March, 2015. Following single oral dose. order vantin online payment usa
Theophylline Derivatives: Protease Inhibitors may decrease the serum concentration of Theophylline Derivatives. Exceptions: Dyphylline. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Karmochkine M, Raguin G "Severe coronary artery disease in a young HIV-infected man with no cardiovascular risk factor who was treated with indinavir. Janssen Products LP. Olysio simeprevir capsules prescribing information. Titusville, NJ; 2013 Nov. This medicine should be taken with water on an empty stomach 1 hour before or 2 hours after a meal or with a light meal. Indinavir may also be taken with other liquids eg, skim milk, juice, coffee, or tea or with a light meal eg, dry toast with jelly, juice, coffee with skim milk and sugar, or corn flakes with skim milk and sugar. Contraindicated if sildenafil being used for pulmonary arterial hypertension. Bristol-Myers Squibb. Sustiva efavirenz capsules and tablets prescribing information. Princeton, NJ; 2012 Jun. seroquel cheap money order online
Everolimus can make you more likely to get infections or may worsen any current infections. Therefore, well to prevent the spread of infection. CHILDREN or before the patient's first menstrual period; safety and effectiveness in children have not been confirmed. Domingo P, Barcelo M "Efavirenz-induced leukocytoclastic vasculitis. OxyCODONE. CYP3A4 Inhibitors Strong may increase the serum concentration of OxyCODONE. Serum concentrations of the active metabolite oxymorphone may also be increased. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Take Crixivan capsules every day as prescribed by your doctor. Continue taking Crixivan unless your doctor tells you to stop. Take the exact amount of Crixivan that your doctor tells you to take, right from the very start. To help make sure you will benefit from Crixivan, you must not skip doses or take "drug holidays". If you don't take Crixivan as prescribed, the activity of Crixivan may be reduced due to resistance. ONGLYZA and periodically thereafter. Erice A, Mayers DL, Strike DG et al. Brief report: primary infection with zidovudine-resistant human immunodeficiency virus type 1. N Engl J Med. Endocrine side effects have included galactorrhea and hyperprolactinemia. It is against the law. It works by enhancing the effects of a certain natural chemical in the body GABA. No evidence of mutagenicity or genotoxicity was observed in in vitro microbial mutagenesis Ames tests, in vitro alkaline elution assays for DNA breakage, in vitro and in vivo chromosomal aberration studies, and in vitro mammalian cell mutagenesis assays. No treatment-related effects on mating, fertility, or embryo survival were seen in female rats and no treatment-related effects on mating performance were seen in male rats at doses providing systemic exposure comparable to or slightly higher than that with the clinical dose. In addition, no treatment-related effects were observed in fecundity or fertility of untreated females mated to treated males. Corticosteroids Orally Inhaled: CYP3A4 Inhibitors Strong may increase the serum concentration of Corticosteroids Orally Inhaled. Management: Orally inhaled fluticasone propionate with a strong CYP3A4 inhibitor is not recommended. Exceptions: Beclomethasone Oral Inhalation; Triamcinolone Systemic. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.
Know the medicines you take. Cyclophosphamide. Specifically, the incidences of neutropenia, infection, and mucositis may be increased. See Specific Drugs and Food under Interactions. Contact your doctor or health care provider right away if any of these apply to you. Your skin and the whites of your eyes may turn yellow. You may have abdominal pain. No dosage adjustment is recommended based on gender. AIDSTRIALS. From AIDS clinical trials information service database. 1996 Apr. Older adults may be more sensitive to the side effects of this drug, especially loss of coordination and drowsiness. These side effects can increase the risk of falling. Lovastatin: Protease Inhibitors may increase the serum concentration of Lovastatin. Crystalluria and nephrolithiasis may occur during treatment with indinavir. The cumulative frequency of nephrolithiasis is substantially higher in pediatric patients 29% than in adult patients 12. Adverse events were observed in some animal reproduction studies. Placental passage in humans with unboosted dosing is minimal. No increased risk of overall birth defects has been observed according to data collected by the antiretroviral pregnancy registry. A small increased risk of preterm birth has been associated with maternal use of protease inhibitor-based combination antiretroviral therapy during pregnancy; however, the benefits of use generally outweigh this risk and protease inhibitors PIs should not be withheld if otherwise recommended. Information related to stillbirth, low birth weight, and small for gestational age infants is limited. Long-term follow-up is recommended for all infants exposed to antiretroviral medications; children who develop significant organ system abnormalities of unknown etiology particularly of the CNS or heart should be evaluated for potential mitochondrial dysfunction. Hyperbilirubinemia may occur in neonates following in utero exposure to indinavir. Hyperglycemia, new onset of diabetes mellitus, or diabetic ketoacidosis have been reported with PIs; it is not clear if pregnancy increases this risk. HIV-infected adults. AIDS Clinical Trials Group protocols 150 and 258. Ann Intern Med. Tell your doctor if you have ever had any unusual or allergic reaction to indinavir or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. L90M at which substitutions are associated with resistance, have been identified. Resistance was mediated by the co-expression of multiple and variable substitutions at these positions. Increased serum triglycerides; increased serum cholesterol. purchase gabapentin safely online
Using marijuana might increase the effects of warfarin Coumadin. Smoking marijuana while taking warfarin Coumadin might increase the chance of bruising and bleeding. Dosing considerations for Marijuana. Since this drug can be absorbed through the and and may harm an unborn baby, women who are or who may become pregnant should not handle this medication or breathe the dust from the tablets. Indinavir should not be used in patients receiving avanafil for treatment of erectile dysfunction 188 or sildenafil for treatment of PAH. Puro V, Ippolito G, Guzzanti E et al. Zidovudine prophylaxis after accidental exposure to HIV: the Italian experience. AIDS. The dose of indinavir will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of indinavir. Gerberding JL, Henderson DK. Management of occupational exposures to bloodborne pathogens: hepatitis B virus, hepatitis C virus, and human immunodeficiency virus. Clin Infect Dis. High levels of also increase the risk for calcium stones. Panobinostat: CYP3A4 Inhibitors Strong may increase the serum concentration of Panobinostat. Management: Reduce the panobinostat dose to 10 mg when it must be used with a strong CYP3A4 inhibitor. Distributed into milk in rats; not known whether distributed into human milk. Crixivan is an oral capsule used for the treatment of HIV Human Immunodeficiency Virus. HIV is the virus that causes AIDS acquired immune deficiency syndrome. Crixivan is a type of HIV drug called a protease PRO-tee-ase inhibitor. How does Crixivan work? What is the most important information I should know about indinavir Crixivan? Appropriate studies have not been performed on the relationship of age to the effects of indinavir in the pediatric population. Safety and efficacy have not been established. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. luvox
Chen Z, Li Y, Schock HB et al. Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials. J Biol Chem. Meperidine. Protease Inhibitors may decrease the serum concentration of Meperidine. Concentrations of the toxic Normeperidine metabolite may be increased. Ergot Derivatives: Protease Inhibitors may increase the serum concentration of Ergot Derivatives. Exceptions: Nicergoline. Rhone-Poulenc Rorer Pharmaceuticals Inc. Caution is warranted and therapeutic concentration monitoring is recommended for antiarrhythmics when coadministered with Crixivan. It is not known whether Crixivan is dialyzable by peritoneal or hemodialysis. Concomitant rifabutin: Dose increase of indinavir to 1000 mg orally every 8 hours is recommended; the standard rifabutin dose should be decreased by half.
Centers for Disease Control and Prevention. Notice to readers: updated guidelines for the use of rifabutin or rifampin for the treatment and prevention of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors. MMWR Morb Mortal Wkly Rep. Prevention of pregnancy. It may also be used to regulate the menstrual cycle. It does NOT protect against HIV infection AIDS and other sexually transmitted diseases STDs. It may be used to treat certain conditions as determined by your doctor. Manidipine: CYP3A4 Inhibitors Strong may increase the serum concentration of Manidipine. Management: Consider avoiding concomitant use of manidipine and strong CYP3A4 inhibitors. If combined, monitor closely for increased manidipine effects and toxicities. Manidipine dose reductions may be required. What is alosetron Lotronex? Tell your doctor about any medicines you are taking or plan to take, including non-prescription medicines, herbal products including St. John's wort Hypericum perforatum or dietary supplements. terazosin
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NOT be taken with CRIXIVAN. Talk with your health provider. Etizolam: CYP3A4 Inhibitors Strong may increase the serum concentration of Etizolam. Management: Consider use of lower etizolam doses when using this combination; specific recommendations concerning dose adjustment are not available. Monitor clinical response to the combination closely. ONGLYZA and metformin were not permitted. HydrOXYzine: CYP3A4 Inhibitors Strong may increase the serum concentration of HydrOXYzine. Management: This combination is specifically contraindicated in some non-U.
Stop taking alosetron and call your doctor if you become constipated while taking alosetron. Drusano GL, Bilello JA, Stein DS et al. Factors influencing the emergence of resistance to indinavir: role of virologic, immunologic, and pharmacologic variables. J Infect Dis. Concomitant use of parenteral midazolam with Crixivan may increase plasma concentrations of midazolam. Midazolam: Protease Inhibitors may increase the serum concentration of Midazolam. Management: Oral midazolam contraindicated with all protease inhibitors. IV midazolam contraindicated with fosamprenavir and nelfinavir; other protease inhibitors recommend caution, close monitoring, and consideration of lower IV midazolam doses with concurrent use.
Patients should be advised to avoid doing things that can spread HIV-1 infection to others. Drugs contraindicated for coadministration with indinavir include alfuzosin, amiodarone, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, lovastatin, simvastatin, pimozide, oral midazolam, triazolam, alprazolam, and sildenafil for treatment of pulmonary arterial hypertension. Indinavir interacts with several antiretroviral agents and appropriate dosage adjustments should be made when these drugs are used together. Patients should be advised to report all concurrent medications they are taking.
Seven metabolites have been identified, one glucuronide conjugate and six oxidative metabolites. In vitro studies indicate that cytochrome P-450 3A4 CYP3A4 is the major enzyme responsible for formation of the oxidative metabolites. Corticosteroids Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of Corticosteroids Systemic. Exceptions: MethylPREDNISolone; PrednisoLONE Systemic; PredniSONE. Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? Goujard C, Legrand M, Panhard X, et al. "High Variability of Indinavir and Nelfinavir Pharmacokinetics in HIV-Infected Patients with a Sustained Virological Response on Highly Active Antiretroviral Therapy.